KEGG   Homo sapiens (human): 11011
Entry
11011             CDS       T01001                                 
Symbol
TLK2, HsHPK, MRD57, PKU-ALPHA
Name
(RefSeq) tousled like kinase 2
  KO
K08864  tousled-like kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Disease
H00773  Autosomal dominant intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    11011 (TLK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     11011 (TLK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  TLK family
   11011 (TLK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr GIT_CC
Other DBs
NCBI-GeneID: 11011
NCBI-ProteinID: NP_001271262
OMIM: 608439
HGNC: 11842
Ensembl: ENSG00000146872
UniProt: Q86UE8
Structure
Position
17:62470914..62615481
AA seq 772 aa
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ
RNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPL
PRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ
NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR
ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT
TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ
KQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEE
AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAF
DLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSF
CTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL
VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISN
KVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRR
CLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN
NT seq 2319 nt   +upstreamnt  +downstreamnt
atgatggaagaattgcatagcctggacccacgacggcaggaattattggaggccaggttt
actggagtaggtgttagtaagggaccacttaatagtgagtcttccaaccagagcttgtgc
agcgtcggatccttgagtgataaagaagtagagactcccgagaaaaagcagaatgaccag
cgaaatcggaaaagaaaagctgaaccatatgaaactagccaagggaaaggcactcctagg
ggacataaaattagtgattactttgagtttgctgggggaagcgcgccaggaaccagccct
ggcagaagtgttccaccagttgcacgatcctcaccgcaacattccttatccaatccctta
ccgcgacgagtagaacagcccctctatggtttagatggcagtgctgcaaaggaggcaacg
gaggagcagtctgctctgccaaccctcatgtcagtgatgctagcaaaacctcggcttgac
acagagcagctggcgcaaaggggagctggcctctgcttcacttttgtttcagctcagcaa
aacagtccctcatctacgggatctggcaacacagagcattcctgcagctcccaaaaacag
atctccatccagcacagacagacccagtccgacctcacaatagaaaaaatatctgcacta
gaaaacagtaagaattctgacttagagaagaaggagggaagaatagatgatttattaaga
gccaactgtgatttgagacggcagattgatgaacagcaaaagatgctagagaaatacaag
gaacgattaaatagatgtgtgacaatgagcaagaaactccttatagaaaagtcaaaacaa
gagaagatggcgtgtagagataagagcatgcaagaccgcttgagactgggccactttact
actgtccgacacggagcctcatttactgaacagtggacagatggttatgcttttcagaat
cttatcaagcaacaggaaaggataaattcacagagggaagagatagaaagacaacggaaa
atgttagcaaagcggaaacctcctgccatgggtcaggcccctcctgcaaccaatgagcag
aaacagcggaaaagcaagaccaatggagctgaaaatgaaacgccctcttctgggaataca
gagctaaaggatacagccccagccttaggagcccacagtttacttaggttaacgttagca
gaataccatgaacaagaagaaatcttcaaactcagattaggtcatcttaaaaaggaggaa
gcagagatccaggcagagctggagagactagaaagggttagaaatctacatatcagggaa
ctaaaaaggatacataatgaagataattcacaatttaaagatcatccaacgctaaatgac
agatatttgttgttacatcttttgggtagaggaggtttcagtgaagtttacaaggcattt
gatctaacagagcaaagatacgtagctgtgaaaattcaccagttaaataaaaactggaga
gatgagaaaaaggagaattaccacaagcatgcatgtagggaataccggattcataaagag
ctggatcatcccagaatagttaagctgtatgattacttttcactggatactgactcgttt
tgtacagtattagaatactgtgagggaaatgatctggacttctacctgaaacagcacaaa
ttaatgtcggagaaagaggcccggtccattatcatgcagattgtgaatgctttaaagtac
ttaaatgaaataaaacctcccatcatacactatgacctcaaaccaggtaatattctttta
gtaaatggtacagcgtgtggagagataaaaattacagattttggtctttcgaagatcatg
gatgatgatagctacaattcagtggatggcatggagctaacatcacaaggtgctggtact
tattggtatttaccaccagagtgttttgtggttgggaaagaaccaccaaagatctcaaat
aaagttgatgtgtggtcggtgggtgtgatcttctatcagtgtctttatggaaggaagcct
tttggccataaccagtctcagcaagacatcctacaagagaatacgattcttaaagctact
gaagtgcagttcccgccaaagccagtagtaacacctgaagcaaaggcgtttattcgacga
tgcttggcctaccgaaaggaggaccgcattgatgtccagcagctggcctgtgatccctac
ttgttgcctcacatccgaaagtcagtctctacaagtagccctgctggagctgctattgca
tcaacctctggggcgtccaataacagttcttctaattga

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Ontology (3)   
   KEGG BRITE (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (35)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (20)   
   OC (1)   
Protein sequence (77)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (75)   
DNA sequence (100)   
   RefSeq(nuc) (76)   
   GenBank (12)   
   EMBL (12)   
3D Structure (2)   
   PDB (2)   
Protein domain (3)   
   Pfam (3)   
All databases (225)   

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